Savage re-entered the game after a brief exit only to be ruled out for the rest of the contest during the following series due to a concussion.
NFL Network Insider Ian Rapoport reported Sunday night that the league initiated a review of all aspects of the concussion protocol as it relates to Savage.
When discussing the Savage situation after the 26-16 loss to the Niners, Texans coach Bill O'Brien told reporters that his starting quarterback was checked following the hit and was cleared by the unaffiliated neurotrauma consultant.
"[They] made the determination that he was OK," O'Brien said. "Not me, obviously the evaluators made the determination to put him back in the game. He went back in the game and came out and they evaluated him a little bit more just because of what they saw."
"Whatever [the evaluators] see and the testing that they do they try to make the best decision with the player and they weren't satisfied with the results of the second test so they decided to pull him, and that's when he went into the locker room."
Yates replaced Savage for the remainder of the game and went 14 of 26 for 175 yards with two touchdowns.