Slaton was benched last week because of problems with ball control. Slaton has lost an NFL-high-tying five fumbles this season.
Moats ran for 126 yards and three touchdowns against the Buffalo Bills last week after Slaton was benched during the first quarter. Moats, a fifth-year pro, makes just his second career start.
Tight end Tom Santi and former starting left tackle Tony Ugoh were healthy scratches for Indianapolis.
The Associated Press contributed to this report.