Yates suffered the season-ending injury on a scramble on the final drive of the first half. Yates walked directly to the locker room under his own power after the injury, which came on a non-contact play.
The Texans' offense failed to move the ball much of the first half with Yates under center. Backed up in their own end on many drives, Yates had little time to throw and was inaccurate on a handful of passes.
Weeden will attempt to lead the Texans on a comeback in a pivotal matchup for a divisional lead in the AFC South.