So far, everything has gone wrong.
The winless Lions have been hit hard by injuries to quarterback Matthew Stafford, wide receiver Nate Burleson and running back Jahvid Best -- three key players on offense -- and their best shot at a victory in Week 1 at Chicago was foiled when officials ruled Calvin Johnson didn't catch a potential game-winning touchdown pass.
"It's been like a domino effect," banged-up running back Aaron Brown said. "We started off with the dumb call and Matt getting hurt, then Nate, and (Best) and me. We keep churning for that break."
Stafford will miss a third consecutive game -- Sunday in Green Bay -- with an injured right shoulder that makes Shaun Hill a starter. Stafford didn't practice Wednesday and had plenty of teammates to watch practice with because Best (toe), Burleson (ankle), Brown (hand) and linebacker DeAndre Levy (groin) were among the players not healthy enough to participate.
Detroit didn't have a big margin for error this season after winning just twice in two years, and injuries to several players have led to an 0-3 record, sinking the franchise to another low.
The Lions are 3-40 since midway through the 2007 season, giving them the worst 43-game record in NFL history, and they're 2-33 since 2008 for the lowest winning percentage over 35 games, according to STATS LLC.
"The worse is over because we bottomed out somewhere in that span," kicker Jason Hanson said. "Everyone can see and feel that we're a better team and there's a reason to have expectations. But it wasn't good to go 0-3 in our situation because the longer you go without getting it done, the more you start to doubt."
Millen was fired two years ago, but his many misses in the draft and free agency left a mess behind for a franchise that already had problems with only one playoff victory since winning the 1957 NFL title.
"You can't get caught up in thinking we're cursed," Raiola said. "I don't even believe in witches."
Stafford didn't throw any passes Wednesday during the part of practice open to the media, then flashed a thumbs-up when a reporter asked him if he threw with his right arm when reporters didn't have access. Stafford, the No. 1 overall pick in the 2009 draft, then declined comment and wasn't in the locker room when it was open for the media.
"Matt's making good progress and is doing a good job in his rehab," Schwartz said. "He won't be ready this week. I'm not going to get into his daily rehab, but he's doing more and more every day as you would expect. ... Matt is continuing in his rehab and throwing is in that rehab."
"I've never won in Green Bay -- that's mind-boggling," Hanson, whom Detroit drafted in 1992. "I used to joke about it, but it's not funny anymore. The streak started the year I came in the league. It seems impossible."
"For me, it's simple," Suh said. "I know how great we are when we're playing as a unit, and I don't think we've played our best game. Until we play our best game and we're still losing, then it becomes a problem."
Needing help, the Lions held a Tuesday workout with four wide receivers, including former high draft picks Troy Williamson and Dexter Jackson, a league source told NFL Network insider Jason La Canfora.
The Associated Press contributed to this report.