"His season has come to an end," Payton said.
The bruising back rushed 56 times for 180 yards (3.2 yards per carry) and four touchdowns for the season and had seen an uptick in snaps in recent weeks prior to the injury.
Payton didn't give an indication as to how the Saints plan to adjust the running back rotation sans Robinson, who averaged 18.1 snaps per game prior to Sunday.
Spiller could see an uptick in snaps, but the Saints have been careful with the veteran coming off an injury. Spiller has averaged 16.7 snaps a game and hasn't seen more than 21 plays in any of his seven contests this season.
Ingram will likely have to carry a heavier load with Robinson gone and should be in line for more goal line work.
Murphy has played only special teams this season, but Payton suggested he could see time as a backup.