The 49ers will attempt to go 5-0 in the Eastern time zone this season when they go to Baltimore for the first game in NFL history between head coaches who are brothers. The game can be seen live on NFL Network; kickoff is at 8:20 p.m. ET, or right about the time you'll be waking up from your post-Thanksgiving meal nap.
Green Bay, meanwhile, travels to Detroit to play one of the few teams that knows what if feels like to get the better of them. The Lions knocked Aaron Rodgers out of the game in a 7-3 victory at Ford Field late last season.