Anderson had been the best player on an Indianapolis defensive line that has graduated from pushover status to a respectable 15th in Football Outsiders' metrics.
Philadelphia's leading tackler, Hicks was enjoying perhaps his finest game -- highlighted by a brilliant 67-yard pick-six -- when he suffered the injury in the fourth quarter of the Eagles' victory at Dallas.
Barring a setback in rehab, both defenders have bright futures in the NFL.
While we've heard the last from Anderson and Hicks this season, there are other rookies still impressing. Here is Around The NFL's latest Rookie of the Year watch for Week 10:
1. Todd Gurley, St. Louis Rams running back: It's rare to see a running back of any experience level averaging 5.63 yards on 100-plus carries this late in the season. Already enjoying a Pro Bowl-caliber season, Vikings nose tackle Linval Joseph should garner All-Pro consideration as the seminal force behind Gurley's pedestrian performance in Week 9.
4. Marcus Mariota, Tennessee Titans quarterback: En route to overcoming a 21-10 deficit versus the Saints, Mariota became the first rookie in history to generate two games with four touchdown passes and no interceptions. As impressive as Mariota was, two factors beyond his control also bode well for the stretch run. Interim coach Mike Mularkey adjusted his protections, resulting in zero sacks for Mariota. Talented second-round wideout Dorial Green-Beckham finally led the team in targets, while his snaps increased for the eighth consecutive week. Mariota needs DGB to emerge as a week-in, week-out force outside the numbers.
5. Karlos Williams, Buffalo Bills running back: Williams returned to the lineup with a bang, averaging 12.22 yards on nine carries versus the Dolphins. The fifth-round power back beat Jets linebacker Demario Davis for a 26-yard score Thursday night, becoming just the second player in history with touchdowns in each of his first six NFL games.
7. Jameis Winston, Tampa Bay Buccaneers quarterback: Winston's completion rate has dropped the past two weeks, but he wasn't sacked versus the Giants and hasn't been intercepted in more than a month. Bucs fans had to love seeing him soar for the pylon with a chance to tie the game in the fourth quarter last week.
10. Byron Jones, Dallas Cowboys defensive back: Jones' Week 9 performance was a mixed bag. He deflected a potential touchdown pass at the goal line in the second quarter, but the Eagles picked on him with a pair of play-action passes to Jordan Matthews, including the game-winner on which Jones slipped and was left in the dust.