Making his 27th career start for his fourth different team, Hoyer was 30 of 49 for 317 yards - a good portion of that with the game out of each late in the fourth quarter - and threw for two scores to Zach Miller.
Prescott was 19 of 24 for 248 yards in Dallas' first home win since last year's opener, which was a week before the first of two broken left collarbones that kept Romo out of 12 games last season. Romo is expected to miss about another month after breaking a bone in his back in the preseason.
Prescott had one of three rushing touchdowns for the Cowboys, who have seven this season after getting eight all of last year, when they finished 4-12.
Copyright 2016 by The Associated Press