Not one to let a slight go without a jab of his own, Ryan threw a barb in Williams' direction during the AFC coaches breakfast at the NFL owners meeting on Tuesday.
"I think he'll play left end, and when you've got (Ndamukong) Suh inside, it's set up to play a 4-3 defense, so I think that's what they'll do with him," Ryan said, via Syracuse.com. "Play a nine technique, everything he wants."
Ryan was referring to Williams' desire to operate strictly as a pass rusher with the freedom to pin his ears back and chase quarterbacks rather than dropping into coverage, as he did at times in the Bills' defense.
For all of the back biting in Buffalo, Ryan insists reports questioning Williams' effort and fit were "kind of overblown."
"I think Mario, I like him personally. He's not perfect, just like the rest of them. I'm perfect," Ryan quipped. "I like Mario, and he's been a great player in this league, a very productive player in this league, and I didn't want to lose him, but that's just the way it is."
That doesn't mean the two sides will lack for motivation when they meet again this season.
Asked if he thinks Williams will have the first rematch circled, Ryan laughed and offered, "I don't know, we may have it circled."