Bradford wore a brace this week and said his ankle "definitely" felt better than it did the previous week. He ditched his walking boot Monday and, barring further injury, expects the ankle to be healed by December.
If Bradford plays, he will be without receiver Danario Alexander, who has been ruled out with a hamstring injury. Running back Jerious Norwood will also miss the game with hamstring problems.
Running back Steven Jackson is probable with a foot injury and is likely to play against Cleveland's soft run defense, ranked 30th in the NFL.
The Associated Press contributed to this report.