Why this game is intriguing: This contest could come down to the wire, but it might not be pretty. Arizona starter John Skelton won his job by being the lesser of two evils. And while Seahawks rookie Russell Wilson was infinitely more impressive than Skelton in the preseason, he doesn't have the firmest grasp on his starting spot, either. Both quarterbacks will have backups waiting in the wings should they falter.
What to watch: The quarterbacks. Watch and see if they can lead an offense. It's not just about throwing for Skelton and Wilson, but keeping their units on the field. With Marshawn Lynch reportedly battling back spasms, that task might get tougher for Wilson. On the Cardinals side, it's about more than trying to get Larry Fitzgerald the ball. Budding star running back Ryan Williams looks healthy again.