The Bills have won four of the last five meetings between these two teams and lead the all-time series, 4-2.
The Bills became the latest victim of the undefeated Patriots, allowing receiver Randy Moss to score a career-high four touchdowns in the Patriots' 56-10 defeat over the host Bills. ... Jaguars quarterback David Garrard returned from injury and extended his streak of games without an interception to seven in host Jacksonville's 24-17 win over San Diego.
Bills running back Marshawn Lynch vs. Jaguars linebackers. Lynch, injured last week against the Patriots, will challenge a Jacksonville linebacking corps that is suddenly without leading tackler Mike Peterson. The Jaguars will have to replace Peterson's productivity in order to remain solid against the run. The Jaguars held LaDainian Tomlinson to only 62 rushing yards, but LT did have five receptions for 93 yards. Look for the Bills to try to get the ball to Lynch in space by throwing the ball to him out of the backfield.