Keep your eye on ...
Seattle's wide receivers: Last week Nate Burleson was expected to pick up the slack without Deion Branch or Bobby Engram in the lineup. But Burleson suffered a season-ending injury, and Hasselbeck is running out of receivers. Second-year WR Courtney Taylor and undrafted free agent Logan Payne are the only healthy receivers currently remaining on Seattle's active roster.
Julius Jones: The Seahawks called 41 passing plays vs. Buffalo, but with Seattle's passing game limited by injuries, expect the Seahawks to run more than the 21 times they did last week. Julius Jones rushed for 85 yards and two TDs as a member of the Cowboys in his only performance vs. San Francisco in 2005.
J.T. O'Sullivan: The 49ers QB is still looking for his first touchdown as a starter. O'Sullivan went 14-of-20, completing 70 percent of his passes vs. Arizona, but turned the ball over twice (one interception, one fumble).
Did you know?
Since the start of 2006, 49ers RB Frank Gore has 3,869 yards from scrimmage (2,893 rushing, 976 receiving), third-most in the NFL during that span. ... The Seahawks have won 24 of their past 28 games at home, including six straight. Seattle has won 15 of the past 19 vs. the NFC West, including five in a row. ... Hasselbeck is 8-2 in his career as a starter vs. San Francisco. In those 10 games, he has completed 219 of 341 (64.2 percent) passes for 2,726 yards with 21 TDs vs. 10 INTs for a 97.2 passer rating.