It's getting tougher every day.
On Saturday, the Colts placed former first-round draft pick Anthony Gonzalez on season-ending injured reserve because of a posterior cruciate ligament injury in his left knee, and they left five other players, including running backs Joseph Addai and Mike Hart, behind as the team flew to Philadelphia.
The injury list is so long that even Polian has had to revise the team's long-held mantra about injuries.
"It's next man up, and right now, we're looking around to see who the next man is," Polian joked as he scouted the Iowa-Indiana game Saturday. "You just have to play through it and hope that the worm turns at some point and we get a little luck as opposed to what we've had over the last seven or eight weeks."
The injury rash has hit every position on the Colts' roster with the exception of one -- quarterback. And it's taking a huge toll.
That won't happen again until next season.
For the second consecutive year, Gonzalez will finish the season on injured reserve -- the 12th Colts player to join the list in 2010. The good news is it appears Gonzalez doesn't need surgery.
"It's just a question of how long it will take to heal," Polian said. "I don't know that surgery is indicated."
Polian said Saturday that NFL officials reviewed the play, but he couldn't discuss publicly the league's response.
Gonzalez has appeared in only three games since the start of the 2009 season and had five catches for 67 yards this year, but he might be the least of the Colts' concerns. The team also has lost All-Pro tight end Dallas Clark (wrist) and safety Melvin Bullitt (shoulder).
"It's been tough, and it's not anything we've ever experienced before, but you just have to play through it," Polian said.
Linebacker Clint Session and cornerback Justin Tryon also didn't travel Saturday.
Cornerback Justin Tryon also will sit out Sunday after starting Monday night in place of the injured Jerraud Powers.
If there is any sign of hope, it is this: Collie (thumb surgery) and Powers' backup, Jacob Lacey, both practiced Thursday and Friday and traveled with the team. Lacey is trying to return from a foot injury. Both are questionable.
And, of course, Manning is expected to make his 200th consecutive start.
"He certainly makes up for lots of deficiencies," Polian said. "One of the things we've got to do is protect him, and we're doing a pretty good job of that. Our backup people have stepped up and played very well. The problem is in the case with Gonzo and Mike Hart, we're losing them to injury, too, which makes it difficult. But, in my experience, these things do straighten out over time, so hopefully we'll get a little bit of luck over the second half of the season."
The Associated Press contributed to this report.