Cornerback Jonathan Wilhite (hip), and defensive linemen Myron Pryor (back) and Mike Wright (concussion) will be sidelined when the Patriots go for their fifth consecutive win.
The three players had been listed as questionable on New England's injury report released Friday.
The Patriots are otherwise healthy as they head into Soldier Field. However, they will be without linebacker Brandon Spikes, who was suspended Friday for the final four games of the regular season for violating the league's policy on performance-enhancing substances. Comcast SportsNet New England reported Saturday that the rookie tested positive for amphetamines contained in a medicine used to treat attention deficit hyperactivity disorder.