GLENDALE, Ariz. -- A new starting quarterback, the same result for Arizona.
Detroit got inside the Arizona 20-yard line only once, and that was after one of Stanton's two interceptions. The loss snapped a four-game winning streak for Detroit (7-3).
Arizona won its sixth in a row and has its best record through 10 games since 1948. The Cardinals, 6-0 at home, also have a three-game lead over Seattle and San Francisco in the NFC West.
Arizona held an opponent without a TD for the first time this season.
Stanton, 3-1 as a starter this season, finished 21 of 32 for 306 yards. Stafford was 18 of 30 for 183 yards with one interception. He was sacked four times, while Stanton, facing the No. 1-rated defense in the NFL, was not sacked.
Stanton, whose wife delivered the couple's second child on Monday, sent Palmer a text right before the game.
"'I'm stepping in for him," Stanton said, "but this is still his team."
Neither team scored in the second half in a matchup of two of the game's best defenses.
Detroit's only real threat came late in the first half.
"That was huge, huge," Arians said. "After that interception, to hold them to three I thought set the tempo for the rest of the football game."
As usual, Arizona blitzed away and put its faith in its talented secondary.
"We put it on them every week," Arians said. "That's the strength of our football team, and we play to their strengths."
The reversal of an officials' call early in the fourth quarter played a big role in the game.
Arizona's Justin Bethel got to a punt by the Cardinals at Detroit's 1-yard line. Bethel tossed the ball away from the end zone, and after it hit another Cardinal or two, Detroit's Jeremy Ross picked it up and ran 49 yards to the Arizona 45. Arians challenged the play, arguing that Bethel had possession of the ball at the 1 and did not bat it back. After a review, Arians won the challenge and the Lions had to start from the 1.
"They said (Bethel) possessed the ball, and that's the ruling," Detroit coach Jim Caldwell said. "It doesn't matter what I think."
A 12-yard pass from Stanton to Larry Fitzgerald on third-and-11 in the final minutes sealed the victory.
The Cardinals took the opening kick and went 80 yards in six plays. The next time they got the ball, they went 77 yards in seven plays.
Stanton was 3 of 4 for 59 yards in the first TD drive and 3 of 4 for 77 yards in the second.
NOTES: The Lions had come from behind in the fourth quarter to win their previous three games. ... The Cardinals have intercepted 15 passes. ... Arizona plays next Sunday at Seattle, where the Cardinals won last year. ... The Cardinals play four of their last six on the road. ... Detroit is at New England next week.
Copyright 2014 by The Associated Press