Indianapolis has won 10 straight matchups versus Tennessee, dominating a weak AFC South over the past half-decade.
Pagano added that Mike Mularkey's squad presents a "huge challenge" as the hottest offense in the league.
The Titans have scored 35 or more points in three consecutive games for the first time in franchise history. They are averaging an NFL-best 33.7 over the last six games.
After struggling to adjust to a new offense with several key additions in September, the organization's vision of power football is coming to fruition.
Marcus Mariota is becoming established as a viable franchise quarterback, posting a 68.0 completion rate, 17:3 TD-to-INT ratio and 119.0 passer rating over the past six weeks. Second only to Ezekiel Elliot in the rushing race, DeMarco Murray has recaptured 2014 Offensive Player of the Year form. Delanie Walker is headed for his second straight Pro Bowl selection.
The postseason might not start for another two months, but this is shaping up as a crucial battle in an AFC South that is there for the taking.