McCarthy said Neal, who's battling a shoulder injury that has kept him out of the past two games, is set to have surgery Tuesday.
"We knew the extent of the injury right away," McCarthy said. "It's (Neal's) shoulder, and sometimes you're able to rehab and play through that, but that's not the case with Mike. It's severe enough, and everyone is in agreement that we need to go in and fix it."
Poppinga's surgery is on the same knee he had reconstructed following his rookie season in 2005. McCarthy said a time for surgery hasn't been set, but it should take place over the next seven to 10 days.
"They found that was more damage than they were able to correct on the initial scope," McCarthy said. "He's seeking a second opinion, but it's pretty clear that he's going to have season-ending surgery."
"I thought they both had a good week of practice, so I know they're chomping at the bit," McCarthy said of Harris and Bigby. "That's something as a staff we'll talk about tonight and tomorrow to try and have a plan there."
"I don't think you run around with your pompoms this week," Packers coach Mike McCarthy said. "That's the last thing that I'm going to do. Everybody had a chance to enjoy the win last night, and I'm sure everybody feels good today. It was easier coming to work today than it was last week. That's our business. Winning is important. A lot of good things come off of winning. But it's onto the next one. It's a simple as that."
The Packers have tried to downplay the emotion associated with facing their former quarterback, especially after losing to Favre twice last season. Even after a win, Rodgers wasn't interested in talking about Favre.
But teammates said Sunday's victory might have meant more to Rodgers than he revealed.
"I think honestly, it does mean a great deal to him," Matthews said. "We might see it as any other game, but for him, there's certainly a little something special. For him, sitting behind Favre, then coming out and putting together two fantastic seasons and losing to him twice, for him to come out against the guy who -- whatever you want to call it, the quarterback who was in front of him -- it means a great deal to him."
"I think it means a lot to him," Flynn said. "Obviously it's a big game for us as a team, the way the season has gone. But personally, I think this was definitely one he had circled that he wanted to win. I'm happy for him. I'm happy he got it."
The Associated Press contributed to this report.