Veteran Sam Madison missed his second straight game with a pulled stomach muscle and backup Kevin Dockery was out with a hip flexor.
Owens was listed as questionable on Friday's injury report with a high ankle sprain, although he returned to take part in limited practice on both Thursday and Friday. Owens was injured against the Carolina Panthers on Dec. 22 and missed the regular-season finale.
Madison missed all three of the Giants' practices during the week with a pulled stomach muscle. He was listed as questionable on Friday's injury report.
In addition to Madison, the Giants also deactivated quarterback Jared Lorenzen (third QB), running back Danny Ware, cornerback Kevin Dockery, offensive tackle Adam Koets, defensive tackle Manuel Wright, wide receiver Sinorice Moss and tight end Jerome Collins.
The Associated Press contributed to this story.