Coach Bruce Arians is 1-3 against Seattle after topping the 'Hawks 10-7 in a bruising, white-knuckled affair in 2013. Arizona dropped both bouts last season without Carson Palmer in the lineup.
The Cardinals quarterback is now healthy and playing the best football of his career, but doubters point to Arizona's fast start and note that none of their victims own a winning record.
But first comes Sunday night, leaving Arians to tell reporters this week that "you'll have two teams with their chests sticking out."
Mathieu disagreed with his coach, saying: "We're 6-2, so we should be the more confident team."