After making the pick, Peters later gave up a pair of touchdown catches to Hopkins.
Ahead of Saturday's playoff bout in Houston, Peters said he only remembers one thing from the matchup with one of the NFL's top receivers.
The interception was the first of eight for Peters this season (tied for the NFL lead) -- a year which should end with the corner winning the Defensive Rookie of the Year award.
"That was huge," Peters said of his first NFL interception. "It wasn't just me making the play. It started with Justin (Houston) putting the right tackle in (Hoyer's) lap. The quarterback couldn't see."
Saturday's matchup between Peters and Hopkins will key the playoff contest. Houston's offense essentially boils down to misdirection plays and throws to Hopkins. If Peters and the rest of KC's secondary slows down the circus-catch machine, it will cripple Houston's entire offensive output.
DeAndre Hopkins when targeted with a rookie in coverage (career):
Passer Rating: 98.8
"He's a good young corner," Hopkins said of Peters. "He's in the Pro Bowl for a reason. The interception, he just happened to be at the right place at the wrong time. It was a miscommunication between my quarterback and I, but you have to give a kid credit for being at the right spot."
Peters then glowed about the receiver in turn: "He's had a (heck) of a year. That's big for him. He had Andre Johnson leave him this year and he had to step up, and that's what he did. You've got to respect that."
Neither of these teams is close to the same as the Week 1 meeting. The Texans have been the best defense since the halfway point of the season, and Hoyer is eminently more comfortable under center -- not looking over his shoulder. For the Chiefs, Alex Smith is in better control of a more potent offense, and young playmakers like Peters and Dee Ford on defense have become household names.
The battle between Hopkins and Peters could end up being the most entertaining of any one-on-one matchup the entire weekend.