"It is going to come down to a lot of things," Titans coach Mike Mularkey told reporters Friday. "It might be a game-time decision. Can he play and not risk himself further injury? That's the biggest thing."
Mariota was limited in practice all week and was hopeful earlier this week that he could give it a go against Indy.
"We're going to take it day by day," Mariota said Thursday. "It's really no different than the process last week. As the days go on, hopefully I'll feel better and better. It is just taking it one day at a time and hopefully I'll be able to go. Hopefully towards the end of the week I'll get more on my plate and hopefully I'll feel comfortable to try and play on Monday."
As Mularkey said, the Titans will have to carefully weigh Mariota's health against the need for his services, but in an important divisional game like this one, we'd expect Mariota to saddle up barring a setback.