The four-time NFL MVP didn't travel with the Colts after undergoing more surgery Thursday. Kerry Collins, signed Aug. 24, started in Manning's place.
Manning is expected to be out at least two months and perhaps for the entire season. This was his third neck surgery in 19 months, and doctors said his prognosis for recovery is good.
Manning, 35, was the first overall draft pick in 1998 and has started every game for the Colts since the start of that season. Manning is third in career passing yards (54,828), completions (4,682) and touchdown passes (399).
Collins, a 38-year-old quarterback who spent the last five seasons with the Tennessee Titans, will start his 178th game Sunday.
Copyright 2011 by The Associated Press