Manning's first game as Broncos quarterback will come in prime time as Denver hosts Pittsburgh on the opening Sunday of the NFL season. The four-time MVP was released by Indianapolis after missing the 2011 season following neck surgery. After conducting a four-city lottery for his services, Manning landed in Denver, which hasn't won a Super Bowl since his new boss, John Elway, was behind center.
"We're excited about that. Anytime you have a guy behind the center named Peyton Manning, you're going to get a lot of attention," Elway said.
Manning won't have an easy assignment against the Steelers, who ranked first in overall defense and against the pass last year.
Pittsburgh's season ended in Denver in January when Tim Tebow threw an 80-yard TD pass to Demaryius Thomas on the first play of overtime in their wild-card playoff game. Manning presents a whole different challenge.
"Hopefully we can back up the playoff game that we had last year," Elway said.
Steelers at Broncos is one of four prime-time games in the league's kickoff week, Sept. 5-10. The schedule, released Tuesday, has the Super Bowl champion Giants hosting the Cowboys in the first Wednesday NFL game since 1948; the league moved the game to avoid a conflict with President Barack Obama's Thursday night speech at the Democratic National Convention.
"We will have a week-in and week-out challenge, not only in who we play, but with the different elements of our schedule," Giants coach Tom Coughlin said. "We play on four different days and we have five night games. Our first three games are Wednesday-Sunday-Thursday. We play two road night games early, come home for a week and then go to San Francisco. Our people are going to have to be really good about it."
The now-traditional Monday night opening doubleheader has Cincinnati at Baltimore, followed by San Diego at Oakland.
A juicy opening-day matchup features San Francisco at Green Bay; the teams combined to go 28-4 in 2011. New Orleans, still awaiting league punishment to its players for the bounty program that targeted opponents for dangerous hits, hosts Washington.
A 14-week package of Thursday night games begins in Week 2 with Chicago at Green Bay. All but one of those games will be on NFL Network, which now has games from September until December instead of just the second half of the schedule.
Two Sunday games will be played outside the United States. St. Louis hosts New England on Oct. 28 in London, while Buffalo hosts Seattle on Dec. 16 in Toronto.
"Those division games just carry so much weight," coach Gary Kubiak said. "We've always had some big games against those guys. Hopefully, we've got ourselves in position right there, that those games are really, really big games for both of us and we can take care of our business."
In all, 10 teams have three consecutive home games, while Green Bay and Houston are the only clubs with three straight road trips.
"As far as playing three on the road, I don't look at that as an extraordinary challenge," coach Mike McCarthy said of Green Bay's first such string since 1998. "It is always challenging, period, when you go on the road."
The wild-card weekend is Jan 5-6, followed the next weekend by the divisional round, then by the conference championships on Jan. 20, The Super Bowl is Feb. 3 in New Orleans, televised by CBS.
AP Pro Football Writer Arnie Stapleton in Denver and AP Sports Writer Tom Canavan in Newark, N.J., contributed to this story.