"We were confident that we could hit some chunk (plays), as we say," Luck said after going 19 of 27. "I think that our tempo helped to get some drives together, but we came in thinking that we had a chance at some big ones."
Luck, who finished second to Griffin in voting for the 2011 Heisman Trophy and 2012 NFL Offensive Rookie of the Year voting, delivered on another milestone day.
He also became the fifth NFL player since 1970 to win 30 regular-season games in a player's first three seasons, and joined the short list of players to throw for 4,000 yards in two of their first seasons, a club that previously included only Manning and Dan Marino.
And aside from turnovers on Indy's first two series, Luck was virtually flawless. He threw TD passes of 30, 3, 48, 73 and 79 yards, the longest of his career, answering every challenge Colt McCoy, Griffin's replacement, posed.
"I think the beauty of it is if you focus too much on the tight ends, there's wide receivers out there and running backs that are going to make you pay," Luck said after leading Indy (8-4) to its eighth win in 10 games.
McCoy started slowly but finished fast. He was 31 of 47 for a career-best 392 yards. His three TD passes were a career high - and one more than Griffin had thrown all season. But Washington (3-9) still lost its fourth in a row.
Meanwhile, Griffin played loyal teammate.
The No. 2 draft pick in 2012, behind Luck, spent the entire day on the sideline studying plays on his tablet, cheering on teammates, bemoaning mistakes and sometimes getting so close to the field he was instructed to move back. He didn't play and didn't take questions after the game.
"Players have to start stepping up and taking some accountability at some point," he said. "We've got to do a better job coaching, that's all I can say. To have those guys wide open like that, it's unheard of on simple coverage calls. It's like a different guy, it seems, all the time."
After Jackson scored off of McCoy's fumble, McCoy answered with a 42-yard TD pass to DeSean Jackson.
The Colts sealed it when Moncrief broke free down the middle again, taking Luck's long pass for a 79-yard score. Moncrief caught three passes for 134 yards.
"We have so many great athletes on this team, such a great coach and doing such a good job of making a great call," Herron said. "We have so many weapons on offense, it is tough to get everybody the ball but we work it out."
NOTES: Jordan Reed had nine catches for 123 yards, and Jackson finished with five catches for 84 yards before leaving late with a bruised right leg. ... Hilton had five catches for 62 yards, setting a new career high for yards in one season (1,145). ... Colts cornerback Vontae Davis left in the third quarter with a concussion. ... Indy had its highest points total since November 2004 and became the first team to score six TDs of 30 or more yards in one game since Washington in 1966.
Copyright 2014 by The Associated Press