Luck led his ninth career fourth-quarter comeback by going 16-of-29 passing for 229 yards, beating Russell Wilson in the first matchup between last season's NFL Rookie of the Year runners-up.
Indy trailed 12-0 early, took the lead after Howell's return and rallied again to take the lead for good on Brown's fourth-quarter touchdown run. The Colts sealed the victory with a two-point conversion pass and a late field goal.
Wilson finished 15-of-31 passing for 210 yards with two touchdowns and one interception. He also ran 13 times for 102 yards.
Copyright 2013 by The Associated Press