The severity of Pace's injury wasn't immediately known after the game.
"We expect him to be out a few weeks," Ryan told the Post. "It's a big loss, but we're fortunate we have a lot of depth at that position."
Veteran Jason Taylor -- signed in the offseason as a situational pass rusher -- will step into Pace's spot in the lineup.
"I wasn't going around telling everybody I was a situation guy," Taylor said. "I want to play."
The Associated Press contributed to this report.