Being the heir to Peyton Manning in Indianapolis is heady stuff for a rookie taking the reins of a franchise that won two games last season.
Luck broke Newton's record of 4,051 yards passing in the second quarter. But it was extending his own rookie record for fourth-quarter comebacks to seven that was more important.
That's all he needed.
After a miserable stretch in which he connected on 1 of 13 passes, the fabulous freshman calmly led Indianapolis (10-5) downfield. He completed a key pass to T.Y. Hilton on third down and made two nice throws to Wayne before hitting the veteran in the back of the end zone.
"We had so many opportunities all game, especially on third down, that we squandered," Wayne said. "We wanted to get that done. That was the opportune time to do it."
"Mission accomplished. That's all I can say," Arians said. "Without getting emotional again, knowing that (Pagano) is going to be back Monday, the work week shouldn't be as stressful."
Charles' big day included an 86-yard touchdown run on the first play of the second half. It was his second 200-yard game of the season, and came one week after he managed 10 yards on nine carries against Oakland.
"It was fun today, competing out there and doing it while we were trying to come back," Charles said. "It was fun going out there and putting out a performance like that."
Peyton Hillis added 101 yards on the ground for the Chiefs (2-13), who had 352 yards rushing in a losing effort - the first time that's happened in NFL history.
A big reason why was Quinn, who was just 10-of-22 passing for 162 yards with two interceptions.
"This game was without a doubt, 100 percent on my shoulders," he said. "You can't play the way I played today and win a football game."
Charles fumbled in the red zone later in the second quarter, and the Colts moved into Vinatieri's range for a 36-yard field goal and a 13-3 halftime lead.
Charles electrified a sparse crowd on the first play of the second half. He angled to the left and then found room down the sideline, cutting back toward the middle of the field and winning a foot-race with the Indianapolis defense for an 86-yard touchdown run.
The Chiefs got the ball back again late in the fourth quarter, but Quinn was stuffed on a quarterback sneak on fourth-and-inches from the Indianapolis 27.
That turned the ball over to Luck, who completed an 11-yard pass to T.Y. Hilton to convert a third down before he and Wayne won it.
"At times it looked a little bleak," Arians said. "Guys hung in there, made plays when they had to make them. Offensively we struggled, and then put together a drive, like we have all year."
Copyright 2012 by The Associated Press