The end to Houston's season comes with some serious news.
"Effective immediately, I have chosen to take an extended leave of absence to focus my attention and intention on my wife's complete recovery from her recent diagnosis of breast cancer," Smith said in the statement. "We are faithful and trust in God's promise of healing and wholeness. I am eternally grateful to the McNair family for their unwavering support during this trying time.
"This was an extremely difficult decision for me for make as I love this organization and every member of this team both on and off the field. I remain committed to our quest to bring a championship to the city of Houston, yet my family needs me now and they are my priority."
Smith has worked for the Texans since 2006, when he became the league's youngest general manager at 36 years old. Houston has gone 92-100 in the regular season and 3-4 in the playoffs, and has won the AFC South four times during his tenure.