Hoke, 34, sprained the knee during the closing minutes of the fourth quarter.
Hoke, who backs up starter Casey Hampton, has been a consistent contributor on the Steelers' defense since 2004. Hoke is the team's only true nose tackle behind Hampton.
Hoke has appeared in 96 games with the Steelers during the seven seasons he has played, notching 45 tackles, two sacks and one fumble recovery.
The Associated Press contributed to this report.