The exhibition game will be televised nationally on NBC.
The Titans will wear their Oilers uniforms of the early 1960s that were distinguished by the derrick logo on their blue helmets. The team played in Houston from 1960-96 before moving to Tennessee.
Buffalo will wear its "throwback" uniforms that feature a simple red buffalo on a white helmet.
The NFL is planning to celebrate the 50th season of its AFL clubs in numerous ways this year.
Information from the Associated Press was included in this report.