Ward fractured his left fibula, the thinner of the two bones extending from the knee to the ankle, in the fourth quarter of New York's 21-16 come-from-behind victory. He rushed 24 times for a career-high 154 yards.
Ward, who is in his fourth year, leads the Giants in rushing with 602 yards despite missing the previous four games with ankle and groin injuries.
"It's tough to deal with," Ward said Sunday. "I'll bounce back from this like I bounced back from all the other ones."
Brandon Jacobs, the opening day starter who has missed the last two games with a hamstring injury, could replace Ward on Sunday at Philadelphia.
Copyright 2007 by The Associated Press.