Floyd, who had been sidelined by a hip injury, was a full participant in practices all week. He has 19 catches for 401 yards and one touchdown this season.
Floyd's return could provide a badly needed boost for the Chargers, who have dropped six straight games. Quarterback Philip Rivers has struggled and the Chargers have played through numerous injuries along the offensive line. Starting left tackle Bryan Dombrowski (foot) is doubtful to face the Jaguars, while guards Tyronne Green (hand) and Louis Vasquez (ankle) are probable.
Defensive end Corey Liuget (fibula), who did not practice Saturday after being limited on Friday, was listed as questionable, and linebacker Na'il Diggs (chest) is doubtful.
The Jaguars placed starting cornerback Will Middleton on injured reserve with a knee injury, the third player done for the year at that position. The team also signed cornerback David Jones to a contract.
The Associated Press contributed to this report.