The Cleveland Browns have suffered another setback less than two weeks before the start of training camp.
Bryant suffered the injury while lifting weights in the gym, a source infomed of his injury told NFL Media's Ian Rapoport.
"We feel awful for Des," said Browns coach Hue Jackson said in a statement released by the team. "This is a young man that worked extremely hard this off season to prepare himself for the 2016 season. He really bought into our coaching, our team-over-self-philosophy and was intent on becoming a leader for our team.
"Ray (Horton) and the defensive staff were expecting a really productive season from him. We all understand that injuries are part of this profession and as a team you have to find a way to overcome them. There is no doubt that we will miss Des this season and we all wish him a speedy recovery."
The veteran led the team with six sacks last year, and Bryant had started all 41 games he has appeared in the past three seasons with the Browns.
"First off, thank you to all the fans, friends, and family who have reached out expressing their well wishes in response to the news of my injury," Bryant said in a statement. "While I'm frustrated and disappointed about having to miss some time out there with my teammates, I take comfort in knowing that preparations have already begun for an epic return."