Frederick was placed on injured reserve, just over six weeks after being diagnosed with Guillain-Barré syndrome, a disorder in which the immune system attacks the body's nervous system in response to illness.
"It's a matter of time for that to happen, and unfortunately, I don't know what that time is," the center said at the time. "I think as long as I continue to keep my eyes forward and continue to work toward that, we're going to be in good shape."
Also headed to injured reserve is wide receiver Terrance Williams. The 29-year-old wideout has been bothered by a foot injury for two weeks.
Frederick and Williams are eligible to return to the active roster after Week 12.