Hilton appeared to suffer a leg injury following his 4-yard TD grab at the end of the first half of Sunday's win over the Falcons. Hilton quickly was escorted into the locker room after the play and subsequently was ruled out after halftime with a quad injury.
Colts coach Frank Reich told reporters after the game that Hilton aggravated a quad injury he had been dealing with throughout the week, per the The Athletic. Hilton also told reporters that the team medical staff held him out of the second half to prevent the quad injury from becoming a tear.
The loss was a big blow for a Colts team that raced out to a 20-3 lead after two quarters largely based on the connection between Hilton and quarterback Jacoby Brissett. Hilton had eight receptions for 65 yards on 10 targets before the injury, and Indianapolis hung on in the second half for a 27-24 win.
Hilton entered the day with his availability in doubt due to the troublesome quad.