Indy (2-2) extended its league-leading streak of consecutive wins over division foes to nine.
Luck was 29 of 41 for a season-best 393 yards. Wayne had seven catches for a season-best 119 yards and scored on a spectacular spinning 28-yard catch.
Tennessee (1-3) has lost three straight since an impressive season-opening win over Kansas City, and this one wasn't even close.
Copyright 2014 by The Associated Press