Mathis had been listed as questionable with a quadriceps injury.
Kicker Adam Vinatieri, wide receiver Anthony Gonzalez, running back Donald Brown and safety Aaron Francisco were inactive Sunday after being ruled out Friday. Defensive back De'von Hall, tackle Michael Toudouze, tight end Tom Santi and defensive end Ervin Baldwin also were inactive.
Indy can break New England's NFL-record streak of 21 consecutive regular-season victories Sunday.
Copyright 2009 by The Associated Press