LONDON -- He ran. He threw. He conquered.
But it was Kaepernick that made the key plays by when the team needed them early.
The Jaguars (0-8) were the "home" team at London's iconic soccer venue, playing in the British capital for the first of their four-year run of regular-season NFL games in London.
They had plenty of fan support, too, with many of the 83,559 spectators waving their giveaway Jaguars flags throughout the evening.
None of that affected what was happening on the field, and on the field it wasn't pretty for the Jags.
Kaepernick made his first big play on San Francisco's first possession, quickly throwing to fullback Bruce Miller on the right sideline for a 43-yard gain.
A few plays later, Kaepernick scrambled for 4 yards on a third-and-5, setting up Gore for a short gain and a first down.
After an incomplete pass, Gore ran 19 yards for the first touchdown.
Kaepernick took over the scoring after that. He ran 13 yards and dove into the corner for the second touchdown late in the first quarter. He passed to Vernon Davis in the corner of the end zone for another. Finally, Kaepernick held onto the ball and scrambled for 7 yards and a touchdown.
And all in the first half.
Besides a 38-yard field goal by Josh Scobee in the waning seconds of the half to make it 28-3, Jacksonville had little to be happy about. But the 49ers fumbled in their own territory late in the third quarter, giving the Jaguars their best chance to score. They took it as Chad Henne tossed a 29-yard touchdown pass to Mike Brown to make it 28-10 with 3 minutes to go.
Gore then ran for 9 yards, 2 yards and the final 2 on three straight plays for the touchdown.
"There are definitely some plays that we needed to make, and the red zone really killed us," Henne said. "If it's just players needing to make plays, we have to make them. We need to man up."
Both teams have a bye next week, as is usual after the trip to London. The Jags then visit Tennessee on Nov. 10, while the 49ers host Carolina.
Harbaugh seemed to love the experience of making the trip, likening it to another huge sporting event.
"The beginning of the game when they were playing the two national anthems, I felt like I was at the Olympics," Harbaugh said. "As a youngster, I always wanted to be in the Olympics and at that moment I was feeling like the moment when they play the gold medal and the silver medal and the bronze medal, the different anthems.
"I got a chill when the gal was singing 'God Save the Queen.' "
NOTES: R&B artist Ne-Yo sang "The Star-Spangled Banner" and Laura Wright sang "God Save the Queen." ... Former San Francisco quarterback Joe Montana and receiver Dwight Clark were the honorary captains for the 49ers. ... It was San Francisco's second game at Wembley. The Niners beat the Denver Broncos 24-16 in 2010.
Copyright 2013 by The Associated Press