Harris suffered the injury during the first quarter and was carted off the field.
Broncos coach Vance Joseph told reporters after the game that Harris will undergo further evaluation when the team returns to Denver.
"We can still win out," Harris said, per The Athletic. "I still have faith in all my guys to finish the season strong. I need them boys to win so I can get back on the field."
Harris, a First Team All-Pro in 2016 and a three-time Pro Bowler, has three interceptions, 48 tackles and a sack on the season.