Johnson suffered the injury in the second quarter, and had to be helped off the field.
The former All-Pro linebacker also tore his Achilles during the 2014 season.
The 34-year-old veteran has spent all of his seasons in the league with Kansas City. It's fair to wonder in the late stage of Johnson's career if this latest devastating setback could cost him more than the remainder of the season.
Johnson finished his 2016 campaign with 89 tackles and a sack, along with a touchdown on a 55-yard interception return.