Newton, the reigning NFL MVP, went 5 for 6 for 36 yards before being replaced by 33-year-old Derek Anderson.
The Panthers launched their preseason with a crisp 14-play march overseen by Newton, who opted not to employ the running aspect of his game.
Working out of the no-huddle offense, Newton completed his first five passes before overthrowing an open Ted Ginn Jr. in the back of the end zone. That forced Carolina to settle for a field goal.
Ryan Mallett, who started the final two games for Baltimore last year, got the call in this one, too. He played the entire first half, going 11 for 15 for 91 yards and a score.
Copyright 2016 by The Associated Press