Irma, now a Category 5 hurricane with winds increasing to 185 miles per hour, according to NOAA and Air Force Hurricane Hunter aircraft, is expected to make landfall in South Florida this weekend.
The NFL has not determined when or where the game between the Bucs and Dolphins will be played. There are currently two options being considered: Sunday at a neutral site, or playing the game later in the season in Miami.
In a statement confirming the decision on Tuesday the NFL cited public safety as the primary factor in moving Sunday's game.
"In the interest of public safety in light of the current state of emergency, the NFL, in consultation with the state and local officials as well as both clubs, has decided that playing an NFL game in South Florida this week is not appropriate," the statement read.
The league added an update on the decision about when and where the game will take place would be decided "as soon as possible."