The Broncos suffered some losses even before they arrived in Indianapolis.
They lost their regular starting guard, Ben Hamilton, for the rest of the season when they placed him on the injured reserve list on Friday. Hamilton suffered a concussion in the early part of training camp, never recovered, and now has been lost for the season.
Denver also lost on another front. It's looking as if wide receiver Javon Walker will be unable to come back from the knee injury he suffered during last week's loss against Jacksonville to play Sunday at Indianapolis. The injury prevented Walker from practicing most of this week and now looks as if it will prevent him from playing as well.
Walker, who recorded 100-yard games in the first two weeks of the season, leads the Broncos in receptions (19) and is second in yards (230). He was held to two receptions for 10 yards in last week's loss to Jacksonville.
In addition to Walker, Broncos safety John Lynch is battling a strained groin he suffered against Jacksonville. Lynch underwent an MRI exam on Monday. Denver coach Mike Shanahan said he would evaluate Lynch on Friday and that the veteran will be a game-time decision.
Some big shakeups for Denver on the eve of a big game versus Indianapolis.
The Associated Press contributed to this report.
