Brees was intercepted once by none other than New Orleans native and former LSU star Tyrann Mathieu. That play ended a scoring threat, but only delayed the inevitable on a day when Arizona's short-handed defense was little match for the prolific passing attack of the Saints (3-0).
Arizona (1-2) had no answer for Graham, who caught nine passes for 134 yards.
Meanwhile, the Saints' rejuvenated defense under new coordinator Rob Ryan produced four sacks and two interceptions of Carson Palmer.
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