Sammy Morris rushed for 85 yards to help the Patriots beat the host Bills, 13-0, in a wind-filled game during Week 17 of last year.
New England has won 11 consecutive games against Buffalo and owns a 56-40-1 overall series lead.
Alex Van Pelt's debut at offensive coordinator:Bills coach Dick Jauron made the unorthodox decision to fire offensive coordinator Turk Schonert a week before the regular season. The duties now belong to Van Pelt, who will be expected to provide immediate results in his first game calling plays.
Terrell Owens' relationship with Trent Edwards: T.O. only played in one preseason game due to a toe injury and has had limited time to build chemistry with Buffalo's starting quarterback. It will be telling to see how Owens reacts once Edwards goes a series or two without throwing his way.
Did you know?
The Bills have won five straight games in the month of September. ... In his last game against the Patriots, Buffalo RB Fred Jackson rushed for a career-high 136 yards. ... Patriots K Stephen Gostkowski led the league with 36 made field goals last year.