The Bills didn't reveal how many tickets were unsold by Thursday afternoon to avoid the blackout over a 75-mile radius. Games need to be sold out 72 hours before kickoff.
The blackout is the first for Buffalo in 27 games, dating to Dec. 24, 2006.
After selling out their first two games, fans are showing disinterest in a team that's 0-4.
Last month, the Bills announced they sold just under 44,000 season tickets. Though it marked the team's fifth-highest total since 1995, it was about 11,000 short of last year.
Copyright 2010 by The Associated Press