Wilson injured the knee during the second quarter and didn't return.
There is no official confirmation that Wilson has suffered a tear to his anterior cruciate ligament or medial collateral ligament, which would end his season.
Wilson's absence leaves the Bengals thin at safety and looking for support behind Roy Williams, Chris Crocker and Chinedum Ndukwe.
In addition, offensive tackle Andrew Whitworth didn't practice Sunday and was seen wearing a protective cast on his thumb, according to The Enquirer. The extent of the injury is unknown.
The Associated Press contributed to this report.