It certainly helped that they were playing one of the worst teams in the league.
"It wasn't an ideal start," Luck said. "It was more of a terrible start to the game offensively for us. ... We sort of woke up in the second half. Those two scoring drives were big for us. That is what we needed."
Indianapolis led 20-3 at halftime -- Jacksonville has been outscored 75-8 in the first half this season -- and made it a laugher with consecutive touchdown drives in the third quarter.
Luck completed 22 of 36 passes for 260 yards, with two TDs and an interception. His other pick was negated by an offside penalty.
Wayne finished with five catches for 100 yards. Richardson ran 20 times for 60 yards. Fleener caught five passes for 77 yards.
"We don't have enough (game balls) to go around anymore," Pagano said. "They have to order some. ... We can certainly give one to everyone on defense. Three points, the yardage and everything we talked about, just outstanding."
Nothing was good for the home team.
Blaine Gabbert, who missed the past two games because of a hand injury, completed 17 of 32 passes for 179 yards, with three interceptions. All of them bounced off receivers' hands.
"Too much inconsistency," Gabbert said. "We killed ourselves on some drives."
Maurice Jones-Drew ran 13 times for 23 yards - against the team he has his most career yards against.
"For us to come out and not be able to run the ball on the Colts, it's mind-boggling. ... It's a lot easier for a defense when they don't have to defend the run so much."
Tight end Marcedes Lewis made his season debut, but ended up back in street clothes after just a few plays. Lewis re-injured his left calf, which kept him sidelined most of the preseason and the first three games.
Defensive end Jason Babin was flagged three times, including once for a late hit on Luck. His offside penalty negated an interception in the first quarter.
"I play aggressive and sometimes it bites me in the (rear)," Babin said. "The offside stuff, I've got to own that. I let my frustrations and wanting to make a play real bad overtake my fundamentals. I can't do that to our team."
And just when things seemed as if they couldn't get any worse for Jacksonville, an apparent fumble recovery was overturned because of an inadvertent whistle. The play was deemed a do-over.
The Jaguars would like to get one of those for the entire season. Jacksonville is 0-4 for the third time in franchise history. The team has never started 0-5.
And the questions about free agent quarterback Tim Tebow continue. A plane flew over the stadium carrying a banner that read "Tebow, why not?"
The Jaguars have lost 12 of their past 19 games by double digits - 11 of those by 16 or more points.
Notes:Colts DE Robert Mathis had three sacks, leaving him one shy of becoming the 30th player in NFL history with 100 career sacks. ... Colts DE Bjoern Werner left the game with a sprained foot and did not return. Colts FB Stanley Havili sprained an ankle. ... Wayne has 138 receptions for 1,956 yards and seven TDs against Jacksonville. ... Gabbert fell to 5-21 as an NFL starter, including 3-2 against the Colts.
Copyright 2013 by The Associated Press