| Arik Armstead | Armstead Academic Project |
| Brandon Aiyuk | Boys & Girls Club of America |
| Brock Purdy | Child Advocates Silicon Valley |
| Charlie Woerner | Hope 139 |
| Charvarius Ward | Down Syndrome & Football Camp for the Stars |
| Christian McCaffrey | 23 and Troops / The Logan Project |
| Colton McKivitz | CWA Veteran Hunt Program |
| Deebo Samuel | Student Program for Academic & Athletic Transitioning |
| Deommodore Lenoir | RYSE Youth Center |
| Drake Jackson | 95 Problems Foundation |
| Dre Greenlaw | Bill Wilson Center |
| Elijah Mitchell | Dreams Come True of Louisiana |
| Fred Warner | COPD Foundation |
| George Kittle | Operation Freedom Paws |
| George Odum | American Liver Foundation |
| Jake Brendel | Living For Zachary |
| Jake Moody | TUFF Foundation |
| Jauan Jennings | 49ers PREP |
| Javon Kinlaw | CityTeam |
| Jaylon Moore | 49ers EDU |
| Jonathan Feliciano | Multidisciplinary Association for Psychedelic Studies |
| Nick Bosa | More than 4 Athletics |
| Oren Burks | South County Football Alumni Association |
| Randy Gregory | Headstrong Foundation |
| Ross Dwelley | Autism Tree Project Foundation |
| Samuel Darnold | NEGU |
| Samuel Womack III | Bayview Hunters Point YMCA |
| Spencer Burford | Mercy Housing |
| T.Y. McGill | T.Y. McGill Jr. Foundation |
| Talanoa Hufanga | Hawaii Community Foundation |
| Trent Williams | Sarcoma Foundation of America |
| Ty Davis-Price | The Michael J. Fox Foundation |
